Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes

被引:249
作者
Wang, RF
Appella, E
Kawakami, Y
Kang, XQ
Rosenberg, SA
机构
[1] National Cancer Institute, Bethesda
[2] Building 10, 2B42, National Cancer Institute, NIH, Bethesda
关键词
D O I
10.1084/jem.184.6.2207
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The infusion of TIL586 along with interleukin-2 into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. Here we report that TRP-2 was identified as a second tumor antigen recognized by a HLA-A31-restricted CTL clone derived from the TIL586 cell Line. The peptide LLPGGRPYR epitope was subsequently identified from the coding region of TRP-2 based on studies of the recognition of truncated TRP-2 cDNAs and the HLA-A31 binding motif. This epitope peptide was cells for lysis by a CTL clone at 1 nM peptide concentration. Although some modified peptides could be recognized by the CTL clone, none were found to be better recognized by T cells than the parental peptide. Like other melamona differentiation antigens, TRP-2 was only expressed in melanoma, melanocytes, and retina, but not in other human tissues tested.
引用
收藏
页码:2207 / 2216
页数:10
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