Advantages and disadvantages of Caenorhabditis elegans for aging research

被引：54

作者：

Johnson, TE ^{[1
]}

机构：

[1] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2003年 / 38卷 / 11-12期

关键词：

RNAi; mutations; genetics of aging; longevity; Daf-16;

D O I：

10.1016/j.exger.2003.10.020

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The nematode Caenorhabditis elegans has been the organism of choice for most aging research, especially genetic appraoches to aging. More than 70 longevity genes have been identified, with more to come, and these genes have been the subjects of intense study. I identify the major reasons for this and discuss limitations of this organism for future progress in research on aging. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1329 / 1332

页数：4

共 36 条

[1]

[Anonymous], 1997, C ELEGANS

[2] Assaying metabolic activity in ageing Caenorhabditis elegans [J].

Braeckman, BP ;

Houthoofd, K ;

De Vreese, A ;

Vanfleteren, JR .

MECHANISMS OF AGEING AND DEVELOPMENT, 2002, 123 (2-3) :105-119

[3]

BRENNER S, 1974, GENETICS, V77, P71

[4] Genome sequence of the nematode C-elegans:: A platform for investigating biology [J].

不详 .

SCIENCE, 1998, 282 (5396) :2012-2018

[5]

EPSTEIN HF, 1995, METHODS CELL BIOL

[6] PRODUCTION OF AGE-SYNCHRONOUS MASS-CULTURES OF CAENORHABDITIS-ELEGANS [J].

FABIAN, TJ ;

JOHNSON, TE .

JOURNALS OF GERONTOLOGY, 1994, 49 (04) :B145-B156

[7]

FRIEDMAN DB, 1988, GENETICS, V118, P75

[8] Insulin/IGF signalling and ageing: seeing the bigger picture [J].

Gems, D ;

Partridge, L .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (03) :287-292

[9] Defining wild-type life span in Caenorhabditis elegans [J].

Gems, D ;

Riddle, DL .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2000, 55 (05) :B215-B219

[10] Genetic pathways that regulate ageing in model organisms [J].

Guarente, L ;

Kenyon, C .

NATURE, 2000, 408 (6809) :255-262

← 1 2 3 4 →