Insulin/IGF signalling and ageing: seeing the bigger picture

被引：134

作者：

Gems, D ^{[1
]}

Partridge, L ^{[1
]}

机构：

[1] UCL, Dept Biol, London NW1 2HE, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 03期

基金：

英国自然环境研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0959-437X(00)00192-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the underlying mechanisms of ageing are not understood, it is known that the longevity of the nematode Caenorhabditis elegans is modulated by an insulin/IGF-signalling pathway. The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals.

引用

页码：287 / 292

页数：6

共 54 条

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