Insulin/IGF signalling and ageing: seeing the bigger picture

被引：134

作者：

Gems, D ^{[1
]}

Partridge, L ^{[1
]}

机构：

[1] UCL, Dept Biol, London NW1 2HE, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 03期

基金：

英国自然环境研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0959-437X(00)00192-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the underlying mechanisms of ageing are not understood, it is known that the longevity of the nematode Caenorhabditis elegans is modulated by an insulin/IGF-signalling pathway. The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals.

引用

页码：287 / 292

页数：6

共 54 条

[31] daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
Lin, K
Dorman, JB
Rodan, A
Kenyon, C
[J]. SCIENCE, 1997, 278 (5341) : 1319 - 1322
[32] The effect of retarded growth upon the length of life span and upon the ultimate body size
McCay, CM
Crowell, MF
Maynard, LA
[J]. JOURNAL OF NUTRITION, 1935, 10 (01) : 63 - 79
[33] The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E
Giorgio, M
Mele, S
Pelicci, G
Reboidl, P
Pandolfi, PP
Lanfrancone, L
Pelicci, PG
[J]. NATURE, 1999, 402 (6759) : 309 - 313
[34] Differential longevity in mouse stocks selected for early life growth trajectory
Miller, RA
Chrisp, C
Atchley, W
[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2000, 55 (09): : B455 - B461
[35] Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity
Miskin, R
Masos, T
[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1997, 52 (02): : B118 - B124
[36] FERTILITY OF TRANSGENIC FEMALE MICE EXPRESSING BOVINE GROWTH-HORMONE OR HUMAN GROWTH-HORMONE VARIANT GENES
NAAR, EM
BARTKE, A
MAJUMDAR, SS
BUONOMO, FC
YUN, JS
WAGNER, TE
[J]. BIOLOGY OF REPRODUCTION, 1991, 45 (01) : 178 - 187
[37] The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C-elegans
Ogg, S
Paradis, S
Gottlieb, S
Patterson, GI
Lee, L
Tissenbaum, HA
Ruvkun, G
[J]. NATURE, 1997, 389 (6654) : 994 - 999
[38] Comparative longevity of pet dogs and humans: Implications for gerontology research
Patronek, GJ
Waters, DJ
Glickman, LT
[J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1997, 52 (03): : B171 - B178
[39] CALORIC RESTRICTION - CONSERVATION OF CELLULAR REPLICATIVE CAPACITY IN-VITRO ACCOMPANIES LIFE-SPAN EXTENSION IN MICE
PENDERGRASS, WR
LI, Y
JIANG, DZ
FEI, RG
WOLF, NS
[J]. EXPERIMENTAL CELL RESEARCH, 1995, 217 (02) : 309 - 316
[40] Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C-elegans insulin gene family
Pierce, SB
Costa, M
Wisotzkey, R
Devadhar, S
Homburger, SA
Buchman, AR
Ferguson, KC
Heller, J
Platt, DM
Pasquinelli, AA
Liu, LX
Doberstein, SK
Ruvkun, G
[J]. GENES & DEVELOPMENT, 2001, 15 (06) : 672 - 686

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