Steroids from the roots of Asparagus officinalis and their cytotoxic activity

被引：45

作者：

Huang, Xue-Feng ^{[1
]}

Lin, Yu-Ying ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

JOURNAL OF INTEGRATIVE PLANT BIOLOGY | 2008年 / 50卷 / 06期

关键词：

Asparagus officinalis; cytotoxic activity; Sarsasapogenin O; steroid;

D O I：

10.1111/j.1744-7909.2008.00651.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One new (Sarsasapogenin 0) and seven known steroids were isolated from the roots of Asparagus officinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxicities against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.

引用

页码：717 / 722

页数：6

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