Factor H family proteins and human diseases

被引：208

作者：

Jozsi, Mihaly ^{[1
]}

Zipfel, Peter F. ^{[2
,3
]}

机构：

[1] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Junior Res Grp Cellular Immunobiol, D-07745 Jena, Germany

[2] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Dept Infect Biol, D-07745 Jena, Germany

[3] Univ Jena, D-07745 Jena, Germany

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.it.2008.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are associated with diverse and severe human diseases and are also used by human pathogenic microbes for complement evasion. Therefore, dissecting the exact functions of the individual CFHR proteins will provide insights into the pathophysiology of such inflammatory and infectious diseases and will define the therapeutic potential of these proteins.

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收藏

页码：380 / 387

页数：8

相关论文

共 68 条

[1] Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease) [J].

Abrera-Abeleda, M. A. ;

Nishimura, C. ;

Smith, J. L. H. ;

Sethi, S. ;

McRae, J. L. ;

Murphy, B. F. ;

Silvestri, G. ;

Skerka, C. ;

Jozsi, M. ;

Zipfel, P. F. ;

Hageman, G. S. ;

Smith, R. J. H. .

JOURNAL OF MEDICAL GENETICS, 2006, 43 (07) :582-589

[2] Perspective - A role for local inflammation in the formation of drusen in the aging eye [J].

Anderson, DH ;

Mullins, RF ;

Hageman, GS ;

Johnson, LV .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2002, 134 (03) :411-431

[3] Membranoproliferative glomerulonephritis type II (dense deposit disease):: An update [J].

Appel, GB ;

Cook, HT ;

Hageman, G ;

Jennette, JC ;

Kashgarian, M ;

Kirschfink, M ;

Lambris, JD ;

Lanning, L ;

Lutz, HU ;

Meri, S ;

Rose, NR ;

Salant, DJ ;

Sethi, S ;

Smith, RJH ;

Smoyer, W ;

Tully, HF ;

Tully, SP ;

Walker, P ;

Welsh, M ;

Würzner, R ;

Zipfel, PF .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (05) :1392-1403

[4] The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system [J].

Behnsen, Judith ;

Hartmann, Andrea ;

Schmaler, Jeannette ;

Gehrke, Alexander ;

Brakhage, Axel A. ;

Zipfel, Peter F. .

INFECTION AND IMMUNITY, 2008, 76 (02) :820-827

[5] The Scl1 protein of M6-type group A Streptococcus binds the human complement regulatory protein, factor H, and inhibits the alternative pathway of complement [J].

Caswell, Clayton C. ;

Han, Runlin ;

Hovis, Kelley M. ;

Ciborowski, Pawel ;

Keene, Douglas R. ;

Marconi, Richard T. ;

Lukomski, Slawomir .

MOLECULAR MICROBIOLOGY, 2008, 67 (03) :584-596

[6] Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction [J].

Coffey, Peter J. ;

Gias, Carlos ;

McDermott, Caroline J. ;

Lundh, Peter ;

Pickering, Matthew C. ;

Sethi, Charanjit ;

Bird, Alan ;

Fitzke, Fred W. ;

Maass, Annelie ;

Chen, Li Li ;

Holder, Graham E. ;

Luthert, Philip J. ;

Salt, Thomas E. ;

Moss, Stephen E. ;

Greenwood, John .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (42) :16651-16656

[7] A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins [J].

Corbett, B. A. ;

Kantor, A. B. ;

Schulman, H. ;

Walker, W. L. ;

Lit, L. ;

Ashwood, P. ;

Rocke, D. M. ;

Sharp, F. R. .

MOLECULAR PSYCHIATRY, 2007, 12 (03) :292-306

[8] A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi [J].

Cordes, FS ;

Roversi, P ;

Kraiczy, P ;

Simon, MM ;

Brade, V ;

Jahraus, O ;

Wallis, R ;

Skerka, C ;

Zipfel, PF ;

Wallich, R ;

Lea, SM .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2005, 12 (03) :276-277

[9] Drusen proteome analysis: An approach to the etiology of age-related macular degeneration [J].

Crabb, JW ;

Miyagi, M ;

Gu, XR ;

Shadrach, K ;

West, KA ;

Sakaguchi, H ;

Kamei, M ;

Hasan, A ;

Yan, L ;

Rayborn, ME ;

Salomon, RG ;

Hollyfield, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :14682-14687

[10] The human complement factor H:: functional roles, genetic variations and disease associations [J].

de Córdoba, SR ;

Esparza-Gordillo, J ;

de Jorge, EG ;

Lopez-Trascasa, M ;

Sánchez-Corral, P .

MOLECULAR IMMUNOLOGY, 2004, 41 (04) :355-367

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