Factor H family proteins and human diseases

被引：208

作者：

Jozsi, Mihaly ^{[1
]}

Zipfel, Peter F. ^{[2
,3
]}

机构：

[1] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Junior Res Grp Cellular Immunobiol, D-07745 Jena, Germany

[2] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Dept Infect Biol, D-07745 Jena, Germany

[3] Univ Jena, D-07745 Jena, Germany

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 08期

关键词：

D O I：

10.1016/j.it.2008.04.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins. Recent evidence shows that factor H family proteins (factor H and CFHRs) are associated with diverse and severe human diseases and are also used by human pathogenic microbes for complement evasion. Therefore, dissecting the exact functions of the individual CFHR proteins will provide insights into the pathophysiology of such inflammatory and infectious diseases and will define the therapeutic potential of these proteins.

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收藏

页码：380 / 387

页数：8

相关论文

共 68 条

[31] Group A streptococcal phagocytosis resistance is independent of complement factor H and factor H-like protein 1 binding [J].

Kotarsky, H ;

Gustafsson, M ;

Svensson, HG ;

Zipfel, PF ;

Truedsson, L ;

Sjöbring, U .

MOLECULAR MICROBIOLOGY, 2001, 41 (04) :817-826

[32]

Kotarsky H, 1998, J IMMUNOL, V160, P3349

[33] Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins [J].

Kraiczy, P ;

Hellwage, J ;

Skerka, C ;

Becker, H ;

Kirschfink, M ;

Simon, MM ;

Brade, V ;

Zipfel, PF ;

Wallich, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (04) :2421-2429

[34] Immune evasion of the human pathogen Pseudomonas aeruginosa:: Elongation factor Tuf is a factor H and plasminogen binding protein [J].

Kunert, Ania ;

Losse, Josephine ;

Gruszin, Christin ;

Huehn, Michael ;

Kaendler, Kerstin ;

Mikkat, Stefan ;

Volke, Daniela ;

Hoffmann, Ralf ;

Jokiranta, T. Sakari ;

Seeberger, Harald ;

Moellmann, Ute ;

Hellwage, Jens ;

Zipfel, Peter F. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (05) :2979-2988

[35] Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein [J].

Laine, Matti ;

Jarva, Hanna ;

Seitsonen, Sanna ;

Haapasalo, Karita ;

Lehtinen, Markus J. ;

Lindeman, Nina ;

Anderson, Don H. ;

Johnson, Patrick T. ;

Jarvela, Irma ;

Jokiranta, T. Sakari ;

Hageman, Gregory S. ;

Immonen, Ilkka ;

Meri, Seppo .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3831-3836

[36] Complement evasion by human pathogens [J].

Lambris, John D. ;

Ricklin, Daniel ;

Geisbrecht, Brian V. .

NATURE REVIEWS MICROBIOLOGY, 2008, 6 (02) :132-142

[37] Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II) [J].

Licht, C. ;

Heinen, S. ;

Jozsi, M. ;

Loeschmann, I. ;

Saunders, R. E. ;

Perkins, S. J. ;

Waldherr, R. ;

Skerka, C. ;

Kirschfink, M. ;

Hoppe, B. ;

Zipfel, P. F. .

KIDNEY INTERNATIONAL, 2006, 70 (01) :42-50

[38] Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome [J].

Manuelian, T ;

Hellwage, J ;

Meri, S ;

Caprioli, J ;

Noris, M ;

Heinen, S ;

Jozsi, M ;

Neumann, HPH ;

Remuzzi, G ;

Zipfel, PF .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (08) :1181-1190

[39] The role of complement in inflammatory diseases from behind the scenes into the spotlight [J].

Markiewski, Maciej M. ;

Lambris, John D. .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (03) :715-727

[40] Domains of group A streptococcal M protein that confer resistance to phagocytosis, opsonization and protection: implications for vaccine development [J].

McArthur, JD ;

Walker, MJ .

MOLECULAR MICROBIOLOGY, 2006, 59 (01) :1-4

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