Dopamine and uric acid act as antioxidants in the repair of DNA radicals: Implications in Parkinson's disease

被引：62

作者：

Anderson, RF

Harris, TA

机构：

[1] Univ Auckland, Dept Auckland Canc Soc Res Ctr, Auckland 1, New Zealand

[2] Univ Auckland, Dept Chem, Auckland 1, New Zealand

来源：

FREE RADICAL RESEARCH | 2003年 / 37卷 / 10期

关键词：

dopamine; uric acid; DNA radicals; Parkinson's disease;

D O I：

10.1080/10715760310001604134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Dopamine (DA) and uric acid (UA) have been found to undergo a protective reaction effecting the fast chemical repair of oxidative free-radical damage to DNA. This antioxidant reaction does not occur with normal concentrations of other, more abundant, antioxidants and our findings suggest that DA and UA are important for the preservation of the DNA in certain brains cells per se . These studies point to the need for drugs that undergo a similar antioxidant reaction with DNA radicals to prevent or arrest DNA damage associated with Parkinson's disease when the levels of DA and UA fall.

引用

收藏

页码：1131 / 1136

页数：6

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