The proliferating role of insulin and insulin-like growth factors in cancer

被引：298

作者：

Gallagher, Emily Jane ^{[1
]}

LeRoith, Derek ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 10期

关键词：

IGF-BINDING PROTEIN-3; FACTOR-I RECEPTOR; HUMAN BREAST-CANCER; ABERRANT CRYPT FOCI; PLASMA C-PEPTIDE; CIRCULATING INSULIN; CELL-PROLIFERATION; COLORECTAL-CANCER; TUMOR-GROWTH; SERUM-LEVELS;

D O I：

10.1016/j.tem.2010.06.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological studies have reported an increased risk of cancer in people with type 2 diabetes (T2DM) and obesity, related in part to hyperinsulinemia, secondary to insulin resistance. Hyperinsulinemia leads to increased expression of insulin-like growth factor (IGF)-I expression. In fact, increased insulin, IGF-I and IGF-II levels are associated with tumor growth in vitro, in animal models, and in epidemiological studies in humans. In this paper, we discuss the roles of insulin, IGF-I and IGF-II, their interaction with the insulin receptor (IR) and IGF-I receptor (IGF-IR), and their signaling pathways and regulation as these pertain to tumor growth. We explain how these pathways have been deciphered by in vitro and in vivo studies, and how they are being exploited in the development of targeted cancer therapies.

引用

页码：610 / 618

页数：9

共 88 条

[1] Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase [J].

Algire, Carolyn ;

Amrein, Lilian ;

Zakikhani, Mahvash ;

Panasci, Lawrence ;

Pollak, Michael .

[2] Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro [J].

Alimova, Irina N. ;

Liu, Bolin ;

Fan, Zeying ;

Edgerton, Susan M. ;

Dillon, Thomas ;

Lind, Stuart E. ;

Thor, Ann D. .

CELL CYCLE, 2009, 8 (06) :909-915

[3] Commentary: Polycystic ovary syndrome: A syndrome of ovarian hypersensitivity to insulin? [J].

Baillargeon, JP ;

Nestler, JE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) :22-24

[4] SOMATOGENIC RECEPTORS OF RAT-LIVER - REGULATION BY INSULIN [J].

BAXTER, RC ;

BRYSON, JM ;

TURTLE, JR .

ENDOCRINOLOGY, 1980, 107 (04) :1176-1181

[5] Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease [J].

Belfiore, Antonino ;

Frasca, Francesco ;

Pandini, Giusepe ;

Sciacca, Laura ;

Vigneri, Riccardo .

ENDOCRINE REVIEWS, 2009, 30 (06) :586-623

[6] PTEN, more than the AKT pathway [J].

Blanco-Aparicio, Carmen ;

Renner, Oliver ;

Leal, Juan F. M. ;

Carnero, Amancio .

CARCINOGENESIS, 2007, 28 (07) :1379-1386

[7] Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds [J].

Bonnette, SG ;

Hadsell, DL .

ENDOCRINOLOGY, 2001, 142 (11) :4937-4945

[8] Increased cancer-related mortality for patients with type 2 diabetes who use sulforrylureas or insulin [J].

Bowker, SL ;

Majumdar, SR ;

Veugelers, P ;

Johnson, JA .

DIABETES CARE, 2006, 29 (02) :254-258

[9] INDUCTION OF THE GROWTH INHIBITOR IGF-BINDING PROTEIN-3 BY P53 [J].

BUCKBINDER, L ;

TALBOTT, R ;

VELASCOMIGUEL, S ;

TAKENAKA, I ;

FAHA, B ;

SEIZINGER, BR ;

KLEY, N .

NATURE, 1995, 377 (6550) :646-649

[10] Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells [J].

Butt, AJ ;

Firth, SM ;

King, MA ;

Baxter, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (50) :39174-39181

← 1 2 3 4 5 6 7 8 9 →