The proliferating role of insulin and insulin-like growth factors in cancer

被引:298
作者
Gallagher, Emily Jane [1 ]
LeRoith, Derek [1 ]
机构
[1] Mt Sinai Sch Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA
关键词
IGF-BINDING PROTEIN-3; FACTOR-I RECEPTOR; HUMAN BREAST-CANCER; ABERRANT CRYPT FOCI; PLASMA C-PEPTIDE; CIRCULATING INSULIN; CELL-PROLIFERATION; COLORECTAL-CANCER; TUMOR-GROWTH; SERUM-LEVELS;
D O I
10.1016/j.tem.2010.06.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epidemiological studies have reported an increased risk of cancer in people with type 2 diabetes (T2DM) and obesity, related in part to hyperinsulinemia, secondary to insulin resistance. Hyperinsulinemia leads to increased expression of insulin-like growth factor (IGF)-I expression. In fact, increased insulin, IGF-I and IGF-II levels are associated with tumor growth in vitro, in animal models, and in epidemiological studies in humans. In this paper, we discuss the roles of insulin, IGF-I and IGF-II, their interaction with the insulin receptor (IR) and IGF-I receptor (IGF-IR), and their signaling pathways and regulation as these pertain to tumor growth. We explain how these pathways have been deciphered by in vitro and in vivo studies, and how they are being exploited in the development of targeted cancer therapies.
引用
收藏
页码:610 / 618
页数:9
相关论文
共 88 条
[11]   Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults [J].
Calle, EE ;
Rodriguez, C ;
Walker-Thurmond, K ;
Thun, MJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) :1625-1638
[12]   Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms [J].
Calle, EE ;
Kaaks, R .
NATURE REVIEWS CANCER, 2004, 4 (08) :579-591
[13]   Insulin-like growth factor-I receptor, E-cadherin and αv integrin form a dynamic complex under the control of α-catenin [J].
Canonici, Alexandra ;
Steelant, Wim ;
Rigot, Veronique ;
Khomitch-Baud, Alexandra ;
Boutaghou-Cherid, Hikma ;
Bruyneel, Erik ;
Van Roy, Frans ;
Garrouste, Francoise ;
Pommier, Gilbert ;
Andre, Frederic .
INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (03) :572-582
[14]   Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor [J].
Carboni, JM ;
Lee, AV ;
Hadsell, DL ;
Rowley, BR ;
Lee, FY ;
Bol, DK ;
Camuso, AE ;
Gottardis, M ;
Greer, AF ;
Ho, CP ;
Hurlburt, W ;
Li, AX ;
Saulnier, M ;
Velaparthi, U ;
Wang, C ;
Wen, ML ;
Westhouse, RA ;
Wittman, M ;
Zimmermann, K ;
Rupnow, BA ;
Wong, TW .
CANCER RESEARCH, 2005, 65 (09) :3781-3787
[15]   BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR [J].
Carboni, Joan M. ;
Wittman, Mark ;
Yang, Zheng ;
Lee, Francis ;
Greer, Ann ;
Hurlburt, Warren ;
Hillerman, Stephen ;
Cao, Carolyn ;
Cantor, Glenn H. ;
Dell-John, Janet ;
Chen, Cliff ;
Discenza, Lorell ;
Menard, Krista ;
Li, Aixin ;
Trainor, George ;
Vyas, Dolatrai ;
Kramer, Robert ;
Attar, Ricardo M. ;
Gottardis, Marco M. .
MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12) :3341-3349
[16]   Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies [J].
Chen, Wensen ;
Wang, Sumin ;
Tian, Tian ;
Bai, Jianling ;
Hu, Zhibin ;
Xu, Yan ;
Dong, Jing ;
Chen, Feng ;
Wang, Xinru ;
Shen, Hongbing .
EUROPEAN JOURNAL OF HUMAN GENETICS, 2009, 17 (12) :1668-1675
[17]   Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer [J].
Clemmons, David R. .
NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (10) :821-833
[18]   Insulin injections promote the growth of aberrant crypt foci in the colon of rats [J].
Corpet, DE ;
Jacquinet, C ;
Peiffer, G ;
Tache, S .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 27 (03) :316-320
[19]   Insulin Receptor Expression by Human Prostate Cancers [J].
Cox, Michael E. ;
Gleave, Martin E. ;
Zakikhani, Mahvash ;
Bell, Robert H. ;
Piura, Esther ;
Vickers, Elaine ;
Cunningham, Matthew ;
Larsson, Ola ;
Fazli, Ladan ;
Pollak, Michael .
PROSTATE, 2009, 69 (01) :33-40
[20]   The influence of glucose-lowering therapies on cancer risk in type 2 diabetes [J].
Currie, C. J. ;
Poole, C. D. ;
Gale, E. A. M. .
DIABETOLOGIA, 2009, 52 (09) :1766-1777