Age-related brain changes in rhesus monkeys: a magnetic resonance spectroscopic study

被引：10

作者：

Herndon, JG ^{[1
]}

Constantinidis, I

Moss, MB

机构：

[1] Yerkes Reg Primate Res Ctr, Div Neurosci, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Radiol, Frederik Philips Magnet Resonance Res Ctr, Atlanta, GA 30322 USA

[3] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA USA

来源：

NEUROREPORT | 1998年 / 9卷 / 09期

关键词：

ageing macaques; myo-inositol; N-acetylaspartate; proton magnetic resonance spectroscopy;

D O I：

10.1097/00001756-199806220-00040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BRAIN metabolites were measured by proton magnetic resonance spectroscopy in five young (4-10 years of age) and six old (24-30 years of age) adult rhesus monkeys. The two age groups had similar levels of N-acetylaspartate and of choline relative to creatine, but the ratio of myo-inositol/creatine was higher in each old monkey than in any of the young animals. There was no significant relationship between the metabolite ratios and cognitive performance. The findings indicate that a consistent pattern of non-invasively detectable biochemical changes occurs in the brain with ageing. Whether these changes have functional significance in age-related pathologies, or are simply markers of brain ageing will be the subject of future studies. (C) 1998 Rapid Science Ltd.

引用

页码：2127 / 2130

页数：4

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