Emerging role of cyclic ADP-ribose (cADPR) in smooth muscle

被引：22

作者：

Bai, N

Lee, HC

Laher, I ^{[1
]}

机构：

[1] Univ British Columbia, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada

[2] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2005年 / 105卷 / 02期

关键词：

cyclic ADP-ribose; cADPR; Ca2+; smooth muscle function;

D O I：

10.1016/j.pharmthera.2004.10.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclic adenosine diphosphate ribose (cADPR) is a naturally, occurring cyclic nucleotide and represents a novel class of endogenous Ca2+ messengers implicated in the regulation of the gating properties of ryanodine receptors (RvRs). This action of cADPR occurs, independantly. from the inositol-1.4.5-trisphosphate (IP3) receptor, The regulation of intracellular Ca2+ release is a fundamental element of cellular Ca-2 homeostasis since a number of smooth muscle functions (tone. proliferation. apoptosis. and gene expression) are modulated by intracellular Ca2+ concentration ([Ca2-](i)). There has been a surge in the efforts aimed at understanding the mechanisms of cADPR-mediated Ca-2 mobilization and its impact on smooth muscle function. This review summarizes the proposed roles of cADPR in the regulation of smooth muscle tone (C) 2004 Published by Elsevier Inc.

引用

页码：189 / 207

页数：19

共 199 条

[11] NAADP receptors are present and functional in the heart [J].