The fibroblast response to tubes exhibiting internal nanotopography

被引：56

作者：

Berry, CC

Dalby, MJ

McCloy, D

Affrossman, S

机构：

[1] Univ Glasgow, Ctr Cell Engn, IBLS, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

来源：

BIOMATERIALS | 2005年 / 26卷 / 24期

基金：

英国生物技术与生命科学研究理事会;

关键词：

actin; cell adhesion; cell morphology; cell spreading; nanotopography; vinculin;

D O I：

10.1016/j.biomaterials.2005.01.046

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The use of three-dimensional scaffolds in cell and tissue engineering is widespread; however, the use of such scaffolds, which bear additional cellular cues such as nanotopography, is as yet in its infancy. This paper details the novel fabrication of nylon tubes bearing nanotopography via polymer demixing, and reports that the topography greatly influenced fibroblast adhesion, spreading, morphology and cytoskeletal organisation. The use of such frameworks that convey both the correct mechanical support for tissue formation and stimulate cells through topographical cues may pave the way for future production of intelligent materials and scaffolds. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4985 / 4992

页数：8

共 30 条

[1] The effect of molecular weight an the topography of thin films of blends of poly(4-bromostyrene) and polystyrene [J].