Targeting cre recombinase to specific neuron Populations with bacterial artificial chromosome constructs

被引：654

作者：

Gong, Shiaoching

Doughty, Martin

Harbaugh, Carroll R.

Cummins, Alexander

Hatten, Mary E.

Heintz, Nathaniel

Gerfen, Charles R.

机构：

[1] Rockefeller Univ, Gene Express Nervous Syst Atlas Project, New York, NY 10021 USA

[2] Rockefeller Univ, Dev Neurobiol Lab, New York, NY 10021 USA

[3] Rockefeller Univ, Howard Hughes Med Inst, Mol Biol Lab, New York, NY 10021 USA

[4] NIMH, Lab Syst Neurosci, Bethesda, MD 20892 USA

来源：

JOURNAL OF NEUROSCIENCE | 2007年 / 27卷 / 37期

关键词：

D O I：

10.1523/JNEUROSCI.2707-07.2007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial artificialchromosome (BAC) constructs. BAC-Cre constructs for 10 genes (Chat, Th, Slc6a4, Slc6a2, Etv1, Ntsr1, Drd2, Drd1, Pcp2, and Cmtm5)produced 14 lines with Cre expression in specific neuronal and glial populations in the brain. These Cre driver lines add functional utility to the >500 BAC-EGFP (enhanced green fluorescent protein) transgenic mouse lines that are part of the Gene Expression Nervous System Atlas Project.

引用

页码：9817 / 9823

页数：7

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