Expanding Pd-catalyzed C-N bond-forming processes: The first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions

被引：725

作者：

Huang, XH ^{[1
]}

Anderson, KW ^{[1
]}

Zim, D ^{[1
]}

Jiang, L ^{[1
]}

Klapars, A ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 22期

关键词：

D O I：

10.1021/ja035483w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first general method for the Pd-catalyzed amination of aryl tosylates and benzenesulfonates was developed utilizing ligand 1, which belongs to a new generation of biaryl monophosphine ligands. In addition, the new catalyst system for the first time enables amidation of aryl arenesulfonates and aqueous amination protocols that do not necessitate the use of cosolvents. The substrate scope has been significantly expanded to include aryl halides containing primary amides and free carboxylic acid groups. In the case of multifunctional substrates, the Pd-catalyzed amination can provide selectivity that is complementary to the Cu-catalyzed C-N bond-forming processes. Copyright © 2003 American Chemical Society.

引用

页码：6653 / 6655

页数：3

共 23 条

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