Improved functional group compatibility in the palladium-catalyzed synthesis of aryl amines

被引：111

作者：

Harris, MC ^{[1
]}

Huang, XH ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 17期

关键词：

D O I：

10.1021/ol0262688

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] The use of Pd(2)dba(3) with bulky, electron-rich ligands 1 or 2 and LIN(TMS)(2) as the base for the coupling of amines with aryl halides containing hydroxyl, amide, or enolizable keto groups is described. This protocol expands the utility of palladium-catalyzed C-N bond formation by allowing for the use of aryl halides containing these functional groups, obviating the need for protecting group manipulations.

引用

页码：2885 / 2888

页数：4

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