Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family

被引：67

作者：

Geijsen, N ^{[1
]}

Koenderman, L ^{[1
]}

Coffer, PJ ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Pulm Dis, NL-3584 Utrecht, Netherlands

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2001年 / 12卷 / 01期

关键词：

cytokine; receptor; specificity; signalling;

D O I：

10.1016/S1359-6101(00)00019-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines mediate the transduction of proliferative. differentiation and survival signals in the hematopoietic system. Although the cytokine family is large and diverse, many different cytokines display broadly overlapping functions. This can be explained by the fact that cytokine receptors often share multiple subunits. Specificity in signal transduction can however be achieved through several mechanisms. This review focuses on how signal specificity carl be achieved within the IL-3, IL-5 and GM-CSF receptor family. This is discussed in terms of receptor expression, recent advances in our understanding of intracellular signalling components, and analysis of null mutant knock-out mice. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：19 / 25

页数：7