True molecular resolution in liquid by frequency-modulation atomic force microscopy

被引：86

作者：

Fukuma, T ^{[1
]}

Kobayashi, K

Matsushige, K

Yamada, H

机构：

[1] Kyoto Univ, Dept Elect Sci & Engn, Kyoto 6158510, Japan

[2] Kyoto Univ, Int Innovat Ctr, Sakyo Ku, Kyoto 6068501, Japan

来源：

APPLIED PHYSICS LETTERS | 2005年 / 86卷 / 19期

关键词：

D O I：

10.1063/1.1925780

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The increasing attention directed towards nanobiological science requires high-resolution imaging tools for the liquid environment. We have been successful in recording molecular-resolution images of polydiacetylene in water with the frequency-modulation atomic force microscopy (FM-AFM). With the oscillation amplitude of a force-sensing cantilever reduced to 0.20 nm, we were able to overcome the large frequency noise due to the low Q-factor of cantilever resonance in water. We have obtained vertical and lateral resolutions of 10 pm and 250 pm, respectively. This method enables nondestructive imaging of soft biological samples with a load force on the order of 1 pN. (c) 2005 American Institute of Physics.

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页码：1 / 3

页数：3

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