Regulation and repair of double-strand DNA breaks

被引：49

作者：

Weaver, DT

机构：

[1] DANA FARBER CANC INST, DIV TUMOR IMMUNOL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOL GENET, BOSTON, MA 02115 USA

来源：

CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 1996年 / 6卷 / 04期

关键词：

DNA double-strand break repair; Ku; DNA-dependent protein kinase; ionizing radiation; V(D)J recombination;

D O I：

10.1615/CritRevEukarGeneExpr.v6.i4.20

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Double-strand break (DSB) repair in mammalian cells involves the DNA-dependent protein kinase (DNA-PK). DNA-PK is composed of three subunits, a catalytic kinase subunit CDNA-PKcs) mutated in the mouse scid complementation group and the Ku heterodimer. Ku-deficient and DNA-PKcs-deficient cell lines and an animal model have illuminated important features of the DSB repair pathway. Additional factors relevant to several essential functions of DNA replication may point to some overlap between DNA synthesis and DNA repair in eukaryotes. The DNA-PK complex may have broader functions based on its possible involvement in transcriptional regulation and cell cycle checkpoints.

引用

页码：345 / 375

页数：31

共 231 条

[71] WILD-TYPE P53 ADOPTS A MUTANT-LIKE CONFORMATION WHEN BOUND TO DNA [J].