Synthesis and biological evaluation of 1α,24-dihydroxy-25-nitrovitamin D3

被引：5

作者：

Oshida, J

Okamoto, M

Ishizuka, S

Azuma, S

机构：

[1] Teijin Ltd, Iwakuni Pharmaceut Factory, Yamaguchi 7408511, Japan

[2] Teijin Ltd, Biomed Res Inst, Hino, Tokyo 1918512, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(99)00013-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1 alpha,24(R)-Dihydroxy-25-nitrovitamin D-3 1 and 1 alpha,24(S)-dihydroxy-25-nitrovitamin D-3 2 were synthesized using the palladium-catalyzed; alkylative enyne cyclization reaction. Their biological properties were studied based on VDR binding affinity and HL-60 cell differentiation activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：381 / 384

页数：4

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