Mitochondrial-nuclear communications

被引:463
作者
Ryan, Michael T. [1 ]
Hoogenraad, Nicholas J. [1 ]
机构
[1] La Trobe Univ, Dept Biochem, Melbourne, Vic 3086, Australia
关键词
mitochondrial biogenesis; mitochondrial stress response; retrograde signaling;
D O I
10.1146/annurev.biochem.76.052305.091720
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondria cannot be made de novo but replicate by a mechanism of recruitment of new proteins, which are added to preexisting sub-compartments. Although mitochondria have their own DNA, more than 98% of the total protein complement of the organelle is encoded by the nuclear genome. Mitochondrial biogenesis requires a coordination of expression of two genomes and therefore cross talk between the nucleus and mitochondria. In mammals, regulation of mitochondrial biogenesis and proliferation is influenced by external factors, such as nutrients, hormones, temperature, exercise, hypoxia, and aging. This complexity points to the existence of a coordinated and tightly regulated network connecting different pathways. Communications are also required for eliciting mitochondrial responses to specific stress pathways. This review covers the mechanisms of mitochondrial biogenesis and the way cells respond to external signals to maintain mitochondrial function and cellular homeostasis.
引用
收藏
页码:701 / 722
页数:22
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