Synthetic hydrogenases: Incorporation of an iron carbonyl thiolate into a designed peptide

被引：93

作者：

Jones, Anne K. ^{[1
]}

Lichtenstein, Bruce R.

Dutta, Arnab

Gordon, Gwyneth

Dutton, P. Leslie

机构：

[1] Univ Penn, Sch Med, Johnson Res Fdn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Arizona State Univ, Sch Earth & Space Explorat, Dept Chem & Biochem, Tempe, AZ 85287 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 48期

关键词：

D O I：

10.1021/ja075116a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[FeFe] hydrogenases catalyze reversible hydrogen oxidation at an unusual organometallic active site. Neither enzymatic studies nor synthesis of small molecule models has managed to elucidate the mechanisms of these enzymes. In this paper, we demonstrate the incorporation of an iron carbonyl thiolate mimic of the hydrogenase active site into a de novo artificial peptide, creating the first peptide-based model system for hydrogenases. Copyright © 2007 American Chemical Society.

引用

页码：14844 / +

页数：3

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