Receptor-Mediated Interactions between Colloidal Gold Nanoparticles and Human Umbilical Vein Endothelial Cells

被引：53

作者：

Bartczak, Dorota ^{[1
]}

Sanchez-Elsner, Tilman ^{[2
]}

Louafi, Fethi ^{[2
]}

Millar, Timothy M. ^{[2
]}

Kanaras, Antonios G. ^{[1
]}

机构：

[1] Univ Southampton, Sch Phys & Astron, Southampton SO17 1BJ, Hants, England

[2] Univ Southampton, Sch Med, Southampton SO16 6YD, Hants, England

来源：

SMALL | 2011年 / 7卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

GROWTH-FACTOR; CANCER; NEUROPILIN-1; BLOOD;

D O I：

10.1002/smll.201001816

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy to manipulate cell operations is demonstrated, based on membrane-receptor-specific interactions between colloidal peptide-capped gold nanoparticles and human umbilical vein endothelial cells. It is shown that colloidal gold nanoparticles of similar charge and size but capped with different peptide sequences can deliberately trigger specific cell functions related to the important biological process of blood vessel growth known as angiogenesis. Specific binding of the peptide-capped particles to two endothelial-expressed receptors (VEGFR-1, NRP-1), which control angiogenesis, is achieved. The cellular fate of the functional nanoparticles is imaged and the influence of the different peptide-coated nanoparticles on the gene expression profile of hypoxia-related and angiogenic genes is monitored. The findings open up new avenues towards the deliberate biological control of cellular functions using strategically designed nanoparticles.

引用

页码：388 / 394

页数：7

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