An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance

被引：26

作者：

Kelly, SL ^{[1
]}

Lamb, DC ^{[1
]}

Cannieux, M ^{[1
]}

Greetham, D ^{[1
]}

Jackson, CJ ^{[1
]}

Marczylo, T ^{[1
]}

Ugochukwu, C ^{[1
]}

Kelly, DE ^{[1
]}

机构：

[1] Univ Wales, Inst Biol Sci, AberBioctr, Aberystwyth SY23 3DA, Dyfed, Wales

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2001年 / 29卷

关键词：

azole; cytochrome P450 51; fungi; mycobacteria; sterol;

D O I：

10.1042/0300-5127:0290122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochrome P450 51 (CYP51) is sterol 14 alpha -demethylase, known also as Erg11p in yeast. First studied in yeast, where it is one of three CYPs in the genome, it has subsequently gained attention as the only CYP found so far in different kingdoms of life. As such it is central to considerations of CYP evolution. Recent use of CYP51-inhibiting antifungal drugs, such as fluconazole, has also been associated with dramatic CYP51 evolution to numerous resistant forms in fungal pathogens. CYP51 has also been discovered in mycobacteria where antifungal azoles ha c e effect and might be of value against tuberculosis. Evolutionary and therapeutic aspects of CYP51 studies are discussed.

引用

页码：122 / 128

页数：7

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