Left sided vocal cord paralysis:: a newly recognized late complication of mediastinal irradiation

Background and purpose: To evaluate the incidence of vocal cord paralysis in a group of breast cancer patients treated with post operative radiation therapy after radical mastectomy. Materials and methods: A group of 150 patients operated with total mastectomy and axillary clearance received, in 1963-1965, post-operative radiotherapy to the parasternal, axillary and supraclavicular lymph node regions. The cohort has now been followed up to 34 years. Results: Eleven of the 12 vocal cord paralyses were left sided, although the breast cancer was almost equally distributed as left- and right-sided (55 vs. 45%). The symptoms did not appear until 2-25 years after irradiation. Series 1 (treated with Co-60 photons) developed 5% recurrent nerve paralysis (RNP) after a median time of 19.0 years compared with 10% and a much earlier appearance (3.5 years) for series 2 (treated with both 60Co photons and electrons). A reconstruction of the dose plan shows that an unintentional overlap of the fields resulted in hotspots in the tracheo-oesophageal groove, where parts of the tissue received 120-130% of the prescribed dose. Conclusions: A left-sided vocal cord paralysis of patients treated with mediastinal radiotherapy might not indicate only tumour recurrence but also mediastinal fibrosis. Small differences in patient positioning cannot be excluded as the cause of the difference in the two series. We postulate that other more subtle damage to the vagus nerve may occur without being recognized as late radiation injury. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.