Circulating microRNA-26a: Potential predictors and therapeutic targets for non-hypertensive intracerebral hemorrhage

被引：36

作者：

Bai, Yongyi ^{[1
]}

Wang, Liang ^{[1
]}

Sun, Lan ^{[2
,3
]}

Ye, Ping ^{[1
]}

Hui, Rutai ^{[2
,3
,4
,5
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Natl Ctr Pharmaceut Screening, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

[4] Chinese Acad Med Sci, Sinogerman Lab Mol Med, Key Lab Clin Cardiovasc Genet, Cardiovasc Inst, Beijing 100730, Peoples R China

[5] Chinese Acad Med Sci, FuWai Hosp, Beijing 100730, Peoples R China

来源：

MEDICAL HYPOTHESES | 2011年 / 77卷 / 04期

基金：

北京市自然科学基金;

关键词：

SMOOTH-MUSCLE-CELLS; STROKE; RISK; DISEASE; POPULATIONS;

D O I：

10.1016/j.mehy.2011.06.017

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The mechanisms of non-hypertensive intracerebral hemorrhages (ICH), which may have different pathologies, mechanisms and genetic background from hypertensive ICH, are not clear. MicroRNAs are a new class of endogenous small RNAs that negatively regulate gene expression at the posttranscriptional level. Previous studies indicate that vascular smooth muscle cell (VSMC) function places important role in non-hypertensive ICH. MiRNA-26a, a pivotal regulator of VSMC function, is one of the cell-free miRNAs that could be detected in healthy humans. Therefore, we get the hypotheses that circulating miR-26a is a potential predictors and therapeutic targets for non-hypertensive ICH. (C) 2011 Published by Elsevier Ltd.

引用

页码：488 / 490

页数：3

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