Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

被引：359

作者：

Medema, Jan Paul ^{[1
]}

Vermeulen, Louis ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Expt Mol Med, Lab Expt Oncol & Radiobiol, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE | 2011年 / 474卷 / 7351期

关键词：

GENOME-WIDE ASSOCIATION; COLORECTAL-CANCER; SOMATIC MUTATION; PROGENITOR CELLS; INDIAN HEDGEHOG; KNOCKOUT MICE; TUMOR-GROWTH; IN-VITRO; COLON; APC;

D O I：

10.1038/nature10212

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The identification of intestinal stem cells as well as their malignant counterparts, colon cancer stem cells, has undergone rapid development in recent years. Under physiological conditions, intestinal homeostasis is a carefully balanced and efficient interplay between stem cells, their progeny and the microenvironment. These interactions regulate the astonishingly rapid renewal of the intestinal epithelial layer, which consequently puts us at serious risk of developing cancer. Here we highlight the microenvironment-derived signals that regulate stem-cell fate and epithelial differentiation. As our understanding of normal intestinal crypt homeostasis grows, these developments may point towards new insights into the origin of cancer and the maintenance and regulation of cancer stem cells.

引用

收藏

页码：318 / 326

页数：9

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