Blood Pressure Characteristics of Female Spontaneously Diabetic Torii-Leprfa Rats

被引：6

作者：

Ishii, Yukihito ^{[1
]}

Maki, Mimi ^{[1
]}

Yamamoto, Hiromi ^{[1
]}

Sasase, Tomohiko ^{[1
]}

Kakutani, Makoto ^{[1
]}

Ohta, Takeshi ^{[1
]}

机构：

[1] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Osaka 5691125, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2011年 / 73卷 / 04期

关键词：

blood pressure; diabetes; SDT-fa/fa rat; GOTO-KAKIZAKI RAT; FATTY RAT; URINARY ANGIOTENSINOGEN; GLOMERULAR HYPERTROPHY; METABOLIC-SYNDROME; GLYCEMIC CONTROL; MODEL; HYPERTENSION; INSULIN; COMPLICATIONS;

D O I：

10.1292/jvms.10-0453

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

Blood pressure in female SDT-fa/fa rats was periodically investigated at ages 8,16, and 24 weeks. Furthermore, an insulin therapy was performed for 5 weeks in the female rats at age 11 weeks, and the change of blood pressure was examined. In addition to obesity, hyperglycemia, hyperinsulinemia, and hyperlipidemia, hyperleptinemia and increased urinary angiotensinogen level were observed during the experimental period. Blood pressure was elevated at ages 8 and 16 weeks, but that at 24 weeks was comparable to that in Sprague-Dawley (SD) rats. Heart rate was decreased from age 8 to 24 weeks. Insulin therapy induced good glycemic control and improvement of hyperlipidemia, but the blood pressure was not reduced. Blood pressure in female SDT-fa/fa rats was elevated temporarily. The blood pressure was not decreased by insulin treatment. SDT-fa/fa rat is a useful model to investigate the relation between diabetes mellitus and hypertension.

引用

页码：501 / 505

页数：5

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