The spread, treatment, and prevention of HIV-1: evolution of a global pandemic

被引：160

作者：

Cohen, Myron S. ^{[1
]}

Hellmann, Nick ^{[2
]}

Levy, Jay A. ^{[3
]}

DeCock, Kevin ^{[4
]}

Lange, Joep ^{[5
]}

机构：

[1] Univ N Carolina, Chapel Hill, NC 27514 USA

[2] Bill & Melinda Gates Fdn, Seattle, WA USA

[3] UCSF, San Francisco, CA USA

[4] WHO, CH-1211 Geneva, Switzerland

[5] Univ Amsterdam, Amsterdam, Netherlands

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 04期

关键词：

D O I：

10.1172/JCI34706

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The most up-to-date estimates demonstrate very heterogeneous spread of HIV-1, and more than 30 million people are now living with HIV-1 infection, most of them in sub-Saharan Africa. The efficiency of transmission of HIV-1 depends primarily on the concentration of the virus in the infectious host. Although treatment with antiviral agents has proven a very effective way to improve the health and survival of infected individuals, as we discuss here, the epidemic will continue to grow unless greatly improved prevention strategies can be developed and implemented. No prophylactic vaccine is on the horizon. However, several behavioral and structural strategies have made a difference - male circumcision provides substantial protection from sexually transmitted diseases, including HIV-1, and the application of antiretroviral agents for prevention holds great promise.

引用

页码：1244 / 1254

页数：11

共 147 条

[1] Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa [J].