Sleep Duration and White Matter Quality in Middle-Aged Adults

被引:75
作者
Yaffe, Kristine [1 ,2 ,3 ,4 ,5 ]
Nasrallah, Ilya [6 ]
Hoang, Tina D. [7 ]
Lauderdale, Diane S. [8 ]
Knutson, Kristen L. [9 ]
Carnethon, Mercedes R. [10 ]
Launer, Lenore J. [11 ]
Lewis, Cora E. [12 ]
Sidney, Stephen [13 ]
机构
[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
[3] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA
[5] San Francisco VA Med Ctr, San Francisco, CA USA
[6] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA
[7] Northern Calif Inst Res & Educ, San Francisco, CA USA
[8] Univ Chicago, Dept Publ Hlth Sci, Chicago, IL 60637 USA
[9] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA
[10] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA
[11] NIA, Intramural Res Program, Bethesda, MD 20892 USA
[12] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
[13] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA
关键词
sleep duration; white matter integrity; white matter hyperintensities; midlife; COGNITIVE DECLINE; OLDER-ADULTS; MEMORY IMPAIRMENT; TEST-PERFORMANCE; HEALTH; WOMEN; RISK; METAANALYSIS; INTEGRITY; DISEASE;
D O I
10.5665/sleep.6104
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: Sleep duration has been associated with risk of dementia and stroke, but few studies have investigated the relationship between sleep duration and brain MRI measures, particularly in middle age. Methods: In a prospective cohort of 613 black and white adults (mean age = 45.4 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, participants reported typical sleep duration, dichotomized into moderate sleep duration (> 6 to <= 8 h) and short sleep duration (<= 6 h) at baseline (2005-2006). Five years later, we obtained brain MRI markers of white matter including fractional anisotropy, mean diffusivity, and white matter hyperintensities. Results: Compared to moderate sleepers, short sleepers had an elevated ratio of white matter hyperintensities to normal tissue in the parietal region (OR = 2.31, 95% CI: 1.47, 3.61) adjusted for age, race/sex, education, hypertension, stroke/TIA, depression, smoking status, and physical activity. White matter diffusivity was also higher, approximately a 0.2 standard deviation difference, in frontal, parietal, and temporal white matter regions, among those reporting shorter sleep duration in (P < 0.05 for all). Conclusions: Short sleep duration was associated with worse markers of white matter integrity in midlife. These mid-life differences in white matter may underlie the link between poor sleep and risk of dementia and stroke.
引用
收藏
页码:1743 / 1747
页数:5
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