Chromatin remodeling in neural development and plasticity

被引：178

作者：

Hsieh, J

Gage, FH

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

[2] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75216 USA

[3] Univ Texas, SW Med Ctr, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75216 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2005.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neural stem cells generate distinct cell types for tissue formation and cell replacement during development and throughout adulthood. Neural development and plasticity are determined by both extrinsic and intrinsic factors that interface to regulate gene programs for controlling neuronal cell fate and function. Recent reports have shown that chromatin remodeling and epigenetic gene regulation play an important role in such diverse areas as neural cell fate specification and synaptic development and function. These epigenetic mechanisms include cell-type-specific transcriptional regulators, histone modifications and chromatin remodeling enzymes, and the activity of retrotransposons.

引用

收藏

页码：664 / 671

页数：8

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