Translocation of bioactive peptides across cell membranes by carbon nanotubes

被引:852
作者
Pantarotto, D
Briand, JP
Prato, M [1 ]
Bianco, A
机构
[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy
[2] CNRS, UPR9021, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France
关键词
D O I
10.1039/b311254c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Functionalised carbon nanotubes are able to cross the cell membrane and to accumulate in the cytoplasm or reach the nucleus without being toxic for the cell up to 10 muM.
引用
收藏
页码:16 / 17
页数:2
相关论文
共 29 条
[1]  
Balavoine F, 1999, ANGEW CHEM INT EDIT, V38, P1912, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1912::AID-ANIE1912>3.0.CO
[2]  
2-2
[3]   Can carbon nanotubes be considered useful tools for biological applications? [J].
Bianco, A ;
Prato, M .
ADVANCED MATERIALS, 2003, 15 (20) :1765-1768
[4]   Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors [J].
Chen, RJ ;
Bangsaruntip, S ;
Drouvalakis, KA ;
Kam, NWS ;
Shim, M ;
Li, YM ;
Kim, W ;
Utz, PJ ;
Dai, HJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :4984-4989
[5]   Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization [J].
Chen, RJ ;
Zhang, YG ;
Wang, DW ;
Dai, HJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (16) :3838-3839
[6]  
DEROSSI D, 1994, J BIOL CHEM, V269, P10444
[7]   Controlled assembly of carbon nanotubes by designed amphiphilic peptide helices [J].
Dieckmann, GR ;
Dalton, AB ;
Johnson, PA ;
Razal, J ;
Chen, J ;
Giordano, GM ;
Muñoz, E ;
Musselman, IH ;
Baughman, RH ;
Draper, RK .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (07) :1770-1777
[8]   Arginine-rich peptides - An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery [J].
Futaki, S ;
Suzuki, T ;
Ohashi, W ;
Yagami, T ;
Tanaka, S ;
Ueda, K ;
Sugiura, Y .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (08) :5836-5840
[9]   Organic functionalization of carbon nanotubes [J].
Georgakilas, V ;
Kordatos, K ;
Prato, M ;
Guldi, DM ;
Holzinger, M ;
Hirsch, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (05) :760-761
[10]   Amino acid functionalisation of water soluble carbon nanotubes [J].
Georgakilas, V ;
Tagmatarchis, N ;
Pantarotto, D ;
Bianco, A ;
Briand, JP ;
Prato, M .
CHEMICAL COMMUNICATIONS, 2002, (24) :3050-3051