Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo

被引:62
作者
Matsuzaki, J
Tsuji, T
Chamoto, K
Takeshima, T
Sendo, F
Nishimura, T [1 ]
机构
[1] Hokkaido Univ, Inst Med Genet, Sect Dis Control, Div Immunoregulat, Sapporo, Hokkaido 0600815, Japan
[2] Yamagata Univ, Sch Med, Dept Immunol & Parasitol, Yamagata 9909585, Japan
关键词
Gr-1; IFN-gamma; memory-type; CD8(+) T cell; antitumor activity;
D O I
10.1016/j.cellimm.2003.08.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During investigating the expression of Gr-1 antigen on various subsets of mouse spleen cells, we found that Gr-1 was expressed on memory-type CD8(+)CD44(high)CD62L(high) T cells in addition to granulocytes. Intraperitoneal administration of anti-Gr-1 mAb caused almost complete elimination of Ly-6C(+) memory-type CD8(+) T cells as well as Ly-6G(+) granulocytes. Anti-Gr-1 mAb-treated mouse spleen cells exhibited greatly reduced IFN-gamma production in response to anti-CD3 mAb both in vitro and in vivo. This reduced cytokine production appeared to be derived from elimination of IFN-gamma-producing Gr-1(+)CD8(+) T cells. Indeed, CD8(+) T cells with IFN-gamma-producing activity and cytotoxicity were generated from isolated Gr-1(+)CD8(+) cells but not from Gr-1(-)CD8(+) T cells. We also demonstrated that therapeutic effect of MBL-2 tumor-immunized spleen cells was greatly reduced by anti-Gr-1 mAb-treatment. Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:98 / 105
页数:8
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