Design for mixing using bubbles in branched microfluidic channels

被引：71

作者：

Garstecki, P ^{[1
]}

Fischbach, MA ^{[1
]}

Whitesides, GM ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

APPLIED PHYSICS LETTERS | 2005年 / 86卷 / 24期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1063/1.1946902

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

This letter describes a method for producing chaotic transport trajectories in planar, microfluidic networks prepared by standard, single-step lithography and operated with a steady-state inflow of the fluids into the device. Gaseous slugs flowing through the network produce temporal variation of pressure distribution and lead to stretching and folding of the continuous fluid. Stabilization of the bubbles by surface-active agents is not necessary, and the method is compatible with the wide range of reactions performed in on-chip bioassays. (c) 2005 American Institute of Physics.

引用

页码：1 / 3

页数：3

共 27 条

[1] The intensification of rapid reactions in multiphase systems using slug flow in capillaries [J].

Burns, JR ;

Ramshaw, C .

LAB ON A CHIP, 2001, 1 (01) :10-15

[2] Microfabricated structures for integrated DNA analysis [J].

Burns, MA ;

Mastrangelo, CH ;

Sammarco, TS ;

Man, FP ;

Webster, JR ;

Johnson, BN ;

Foerster, B ;

Jones, D ;

Fields, Y ;

Kaiser, AR ;

Burke, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5556-5561

[3] Gradients of substrate-bound laminin orient axonal specification of neurons [J].

Dertinger, SKW ;

Jiang, XY ;

Li, ZY ;

Murthy, VN ;

Whitesides, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12542-12547

[4] Separation of proteins on surface-modified poly(dimethylsiloxane) microfluidic devices [J].

Dou, YH ;

Bao, N ;

Xu, JJ ;

Meng, F ;

Chen, HY .

ELECTROPHORESIS, 2004, 25 (17) :3024-3031

[5] Rapid prototyping of microfluidic systems in poly(dimethylsiloxane) [J].

Duffy, DC ;

McDonald, JC ;

Schueller, OJA ;

Whitesides, GM .

ANALYTICAL CHEMISTRY, 1998, 70 (23) :4974-4984

[6] Formation of monodisperse bubbles in a microfluidic flow-focusing device [J].

Garstecki, P ;

Gitlin, I ;

DiLuzio, W ;

Whitesides, GM ;

Kumacheva, E ;

Stone, HA .

APPLIED PHYSICS LETTERS, 2004, 85 (13) :2649-2651

[7]

GARSTECKI P, UNPUB

[8] Transport and reaction in microscale segmented gas-liquid flow [J].

Günther, A ;

Khan, SA ;

Thalmann, M ;

Trachsel, F ;

Jensen, KF .

LAB ON A CHIP, 2004, 4 (04) :278-286

[9] Systematic investigation of protein phase behavior with a microfluidic formulator [J].

Hansen, CL ;

Sommer, MOA ;

Quake, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (40) :14431-14436

[10] Microfabrication inside capillaries using multiphase laminar flow patterning [J].

Kenis, PJA ;

Ismagilov, RF ;

Whitesides, GM .

SCIENCE, 1999, 285 (5424) :83-85

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