Formation of monodisperse bubbles in a microfluidic flow-focusing device

被引：543

作者：

Garstecki, P ^{[1
]}

Gitlin, I

DiLuzio, W

Whitesides, GM

Kumacheva, E

Stone, HA

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

[2] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada

[3] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

APPLIED PHYSICS LETTERS | 2004年 / 85卷 / 13期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.1796526

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

This letter describes a method for generating monodisperse gaseous bubbles in a microfluidic flow-focusing device. The bubbles can be obtained in a range of diameters from 10 to 1000 mum. The volume V-b of the bubbles scales with the flow rate q and the viscosity mu of the liquid, and the pressure p of the gas stream as V(b)proportional top/qmu. This method allows simultaneous, independent control of the size of the individual bubbles and volume fraction of the dispersed phase. Under appropriate conditions, bubbles self-assemble into highly ordered, flowing lattices. Structures of these lattices can be adjusted dynamically by changing the flow parameters. (C) American Institute of Physics.

引用

页码：2649 / 2651

页数：3

共 25 条

[1] Formation of dispersions using "flow focusing" in microchannels
Anna, SL
Bontoux, N
Stone, HA
[J]. APPLIED PHYSICS LETTERS, 2003, 82 (03) : 364 - 366
[2] Small-scale free surface flows with breakup: Drop formation and emerging applications
Basaran, OA
[J]. AICHE JOURNAL, 2002, 48 (09) : 1842 - 1848
[3] A prototype two-dimensional capillary electrophoresis system fabricated in poly(dimethylsiloxane)
Chen, XX
Wu, HK
Mao, CD
Whitesides, GM
[J]. ANALYTICAL CHEMISTRY, 2002, 74 (08) : 1772 - 1778
[4] Ordered and disordered patterns in two-phase flows in microchannels
Dreyfus, R
Tabeling, P
Willaime, H
[J]. PHYSICAL REVIEW LETTERS, 2003, 90 (14) : 4
[5] Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
Duffy, DC
McDonald, JC
Schueller, OJA
Whitesides, GM
[J]. ANALYTICAL CHEMISTRY, 1998, 70 (23) : 4974 - 4984
[6] A microfabricated fluorescence-activated cell sorter
Fu, AY
Spence, C
Scherer, A
Arnold, FH
Quake, SR
[J]. NATURE BIOTECHNOLOGY, 1999, 17 (11) : 1109 - 1111
[7] Perfectly monodisperse microbubbling by capillary flow focusing -: art. no. 274501
Gañán-Calvo, AM
Gordillo, JM
[J]. PHYSICAL REVIEW LETTERS, 2001, 87 (27)
[8] GARSTECKI P, UNPUB
[9] A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion
Hansen, CL
Skordalakes, E
Berger, JM
Quake, SR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) : 16531 - 16536
[10] Geometrically mediated breakup of drops in microfluidic devices
Link, DR
Anna, SL
Weitz, DA
Stone, HA
[J]. PHYSICAL REVIEW LETTERS, 2004, 92 (05) : 4 - 545034

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