An efficient synthesis of N,N′-linked oligoureas

被引：34

作者：

Wilson, ME ^{[1
]}

Nowick, JS ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(98)01396-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper reports an efficient synthesis of N-alkyl-N,N'-linked oligoureas [-NR-CO-NH-CH2CH2-](n), which involves the repetition of three steps: (1) main-chain extension by ring-opening of N-(2-nitrobenzenesulfonyl)-2-imidazolidone (1) by a secondary amine RR'NH to afford sulfonamide RR'N-CO-NH-CH2CH2-NH-SO2Ar (2) side-chain attachment by N-alkylation of the sulfonamide with alkyl halide R"X, and (3) removal of the sulfonyl group to give a new secondary amine RR'N-CO-NH-CH2CH2-NHR". A tetraurea was prepared in 10 steps and 58% overall yield by this method. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6613 / 6616

页数：4

共 18 条

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