Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration

被引：137

作者：

Davis, MP ^{[1
]}

Walsh, D ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Harry R Horvitz Ctr Palliat Med, Cleveland, OH 44195 USA

来源：

SUPPORTIVE CARE IN CANCER | 2001年 / 9卷 / 02期

关键词：

methadone; N-methyl-d-asparate receptor; morphine; pharmacokinetics; pharmacodynamics;

D O I：

10.1007/s005200000180

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions. Several guidelines of administration have been established. Physicians who are involved in pain management should have a fundamental understanding of methadone's unique properties.

引用

页码：73 / 83

页数：11