Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

被引：489

作者：

Hellal, Farida ^{[1
]}

Hurtado, Andres ^{[2
]}

Ruschel, Joerg ^{[1
]}

Flynn, Kevin C. ^{[1
]}

Laskowski, Claudia J. ^{[1
]}

Umlauf, Martina ^{[1
]}

Kapitein, Lukas C. ^{[3
,4
]}

Strikis, Dinara ^{[5
]}

Lemmon, Vance ^{[5
]}

Bixby, John ^{[5
]}

Hoogenraad, Casper C. ^{[3
,4
]}

Bradke, Frank ^{[1
]}

机构：

[1] Max Planck Inst Neurobiol, Axonal Growth & Regenerat Grp, D-82152 Martinsried, Germany

[2] Johns Hopkins Univ, Hugo W Moser Res Inst Kennedy Krieger, Int Ctr Spinal Cord Injury, Dept Neurol, Baltimore, MD 21205 USA

[3] Erasmus MC, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands

[4] Univ Utrecht, Fac Sci, NL-3584 CH Utrecht, Netherlands

[5] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA

来源：

SCIENCE | 2011年 / 331卷 / 6019期

关键词：

TGF-BETA; FUNCTIONAL RECOVERY; GROWTH; PROLIFERATION; INHIBITION; ELEVATION; CAMP; CNS;

D O I：

10.1126/science.1201148

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics. Here, moderate microtubule stabilization decreased scar formation after spinal cord injury in rodents through various cellular mechanisms, including dampening of transforming growth factor-beta signaling. It prevented accumulation of chondroitin sulfate proteoglycans and rendered the lesion site permissive for axon regeneration of growth-competent sensory neurons. Microtubule stabilization also promoted growth of central nervous system axons of the Raphe-spinal tract and led to functional improvement. Thus, microtubule stabilization reduces fibrotic scarring and enhances the capacity of axons to grow.

引用

页码：928 / 931

页数：4

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