Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

被引：251

作者：

Freund, Patrick

Schmidlin, Eric

Wannier, Thierry

Bloch, Jocelyne

Mir, Anis

Schwab, Martin E.

Rouiller, Eric M. ^{[1
]}

机构：

[1] Univ Fribourg, Fac Sci, Dept Med, Univ Physiol, CH-1700 Fribourg, Switzerland

[2] Univ Fribourg, Fac Sci, Dept Med, Program Neurosci, CH-1700 Fribourg, Switzerland

[3] Univ Zurich, ETH Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland

[4] Univ Lausanne Hosp, Neurosurg Clin, Dept Neurosurg, CH-1011 Lausanne, Switzerland

[5] Novartis Inst BioMed Res, Neurosci Res, CH-4002 Basel, Switzerland

来源：

NATURE MEDICINE | 2006年 / 12卷 / 07期

关键词：

D O I：

10.1038/nm1436

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A-specific antibody as compared to monkeys treated with control antibody.

引用

页码：790 / 792

页数：3

共 15 条

[1] RECOVERY FROM SPINAL-CORD INJURY MEDIATED BY ANTIBODIES TO NEURITE GROWTH-INHIBITORS [J].