Staphylococcus aureus biofilms Properties, regulation and roles in human disease

被引：700

作者：

Archer, Nathan K. ^{[1
,2
]}

Mazaitis, Mark J. ^{[3
]}

Costerton, J. William ^{[4
]}

Leid, Jeff G. ^{[5
]}

Powers, Mary Elizabeth ^{[6
]}

Shirtliff, Mark E. ^{[1
,7
]}

机构：

[1] Univ Maryland, Sch Dent, Dept Microbial Pathogenesis, Baltimore, MD 21201 USA

[2] Univ Maryland, Grad Program Life Sci, Microbiol & Immunol Program, Baltimore, MD 21201 USA

[3] Univ Maryland, Inst Genome Sci, Baltimore, MD 21201 USA

[4] Allegheny Singer Res Inst, Ctr Genom Sci, Pittsburgh, PA 15212 USA

[5] No Arizona Univ, Dept Biol Sci, Flagstaff, AZ 86011 USA

[6] Univ Waterloo, Waterloo, ON N2L 3G1, Canada

[7] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

VIRULENCE | 2011年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Staphylococcus aureus; biofilms; MRSA; therapy; vaccine; host response; pathogenesis; POLYSACCHARIDE INTERCELLULAR ADHESIN; COMPLETE GENOME SEQUENCE; PSEUDOMONAS-AERUGINOSA; BACTERIAL BIOFILMS; ICA LOCUS; INDEPENDENT BIOFILM; DNA RELEASE; ANTIMICROBIAL THERAPY; EXTRACELLULAR DNA; PROTEOME ANALYSIS;

D O I：

10.4161/viru.2.5.17724

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

引用

页码：445 / 459

页数：15

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