The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes

被引：50

作者：

Anwar, S. ^{[1
]}

Prince, L. R. ^{[1
]}

Foster, S. J. ^{[2
]}

Whyte, M. K. B. ^{[1
]}

Sabroe, I. ^{[1
]}

机构：

[1] Univ Sheffield, Royal Hallamshire Hosp, Acad Unit Resp Med, Sect Infect Inflammat & Immun,Sch Med & Biomed Sc, Sheffield S10 2JF, S Yorkshire, England

[2] Univ Sheffield, Dept Mol Microbiol Mol Biol & Biotechnol, Sheffield S10 2JF, S Yorkshire, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2009年 / 157卷 / 02期

关键词：

apoptosis; inflammation; necrosis; neutrophil; S; aureus; PANTON-VALENTINE LEUKOCIDIN; CHRONIC GRANULOMATOUS-DISEASE; COMMUNITY-ASSOCIATED MRSA; PHENOL-SOLUBLE MODULIN; TOLL-LIKE RECEPTOR-2; ALPHA-TOXIN; HUMAN NEUTROPHILS; POLYMORPHONUCLEAR LEUKOCYTES; LIPOTEICHOIC ACID; IMMUNE EVASION;

D O I：

10.1111/j.1365-2249.2009.03950.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent developments in the study of host-pathogen interactions have fundamentally altered our understanding of the nature of Staphylococcus aureus infection, and previously held tenets regarding the role of the granulocyte are being cast aside. Novel mechanisms of pathogenesis are becoming evident, revealing the extent to which S. aureus can evade neutrophil responses successfully by resisting microbicides, surviving intracellularly and subverting cell death pathways. Developing a detailed understanding of these complex strategies is especially relevant in light of increasing staphylococcal virulence and antibiotic resistance, and the knowledge that dysfunctional neutrophil responses contribute materially to poor host outcomes. Unravelling the biology of these interactions is a challenging task, but one which may yield new strategies to address this, as yet, defiant organism.

引用

页码：216 / 224

页数：9

共 109 条

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