Active carbonate resins for solid-phase synthesis through the anchoring of a hydroxyl function. Synthesis of cyclic and alcohol peptides

被引：48

作者：

Alsina, J ^{[1
]}

Chiva, C ^{[1
]}

Ortiz, M ^{[1
]}

Rabanal, F ^{[1
]}

Giralt, E ^{[1
]}

Albericio, F ^{[1
]}

机构：

[1] UNIV BARCELONA,DEPT ORGAN CHEM,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(96)02431-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N,N'-Disuccinimidyl carbonate (DSC) has been successfully used for the efficient conversion of 4-hydroxymethylpolystyrene and 4-hydroxymethyl-3-nitrobenzamido (Nbb) resins into active carbonate resins, which are suitable for the incorporation of molecules via a hydroxyl function. This methodology has been applied to the preparation of the growth hormone inhibitor, Sandostatin. (C) 1997, Elsevier Science Ltd.

引用

页码：883 / 886

页数：4

共 37 条

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