Haematologists' approaches to the management of adolescents and young adults with acute leukaemia

被引:16
作者
Benjamin, S
Kroll, ME
Cartwright, RA
Clough, JV
Gorst, DW
Proctor, SJ
Ross, JRY
Taylor, PRA
Wheatley, K
Whittaker, JA
Stiller, CA
机构
[1] Univ Oxford, Childhood Canc Res Grp, Oxford OX2 6HJ, England
[2] Univ Leeds, Inst Epidemiol, Leukaemia Res Fund Ctr Clin Epidemiol, Leeds, W Yorkshire, England
[3] Countess Chester Hosp, Chester, Cheshire, England
[4] Royal Lancester Infirm, Lancaster, England
[5] Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[6] Northampton Gen Hosp, Northampton, England
[7] Univ Birmingham, Clin Trials Unit, Birmingham, W Midlands, England
[8] Cardiff Univ, Cardiff CF4 4XN, S Glam, Wales
关键词
acute leukaemia; haematologists' attitudes; adolescents; clinical trials; treatment;
D O I
10.1046/j.1365-2141.2000.02489.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Approaches to the management of adolescents and young adults with acute leukaemia were investigated by sending a questionnaire to hospitals identified as having diagnosed or treated patients aged 15-29 years. The responses demonstrated the types of hospital treating these patients, the haematologists' perceived practice for entry of patients to Medical Research Council (MRC) leukaemia trials and reasons for non-entry Data were linked to MRC trials data to determine the proportion of patients aged 15-29 years at diagnosis in responding hospitals actually treated in MRC leukaemia trials in the 5 years preceding the questionnaire, Eighty-two per cent of haematologists stated that they entered patients 'always' or 'whenever possible' for acute myeloid leukaemia (AML) and 76% for acute lymphoblastic leukaemia (ALL), but actual entry rates from the study hospitals were 46% of 239 AML patients and 36% of 182 ALL patients. The reasons most commonly reported for not entering eligible patients to national leukaemia trials were clinician preference for one arm of an MRC trial, a regional study or non-trial protocol, and concern about workload and ethical approval.
引用
收藏
页码:1045 / 1050
页数:6
相关论文
共 20 条
[11]   PATIENT ACCRUAL AND QUALITY OF PARTICIPATION IN A MULTICENTER STUDY ON MYELOMA - A COMPARISON BETWEEN MAJOR AND MINOR PARTICIPATING CENTERS [J].
HJORTH, M ;
HOLMBERG, E ;
RODJER, S ;
TAUBE, A ;
WESTIN, J .
BRITISH JOURNAL OF HAEMATOLOGY, 1995, 91 (01) :109-115
[12]   Physicians' attitudes toward clinical trials and their relationship to patient accrual in a Nordic multicenter study on myeloma [J].
Hjorth, M ;
Holmberg, E ;
Rodjer, S ;
Taube, A ;
Westin, J .
CONTROLLED CLINICAL TRIALS, 1996, 17 (05) :372-386
[13]  
*HLTH SERV GUID, 1997, HLTH SERV GUID APR
[14]   Recruitment for controlled clinical trials: Literature summary and annotated bibliography [J].
Lovato, LC ;
Hill, K ;
Hertert, S ;
Hunninghake, DB ;
Probstfield, JL .
CONTROLLED CLINICAL TRIALS, 1997, 18 (04) :328-352
[15]  
Ruckdeschel J C, 1996, J Cancer Educ, V11, P73
[16]   Patterns of care and survival for adolescents and young adults with acute leukaemia - a population-based study [J].
Stiller, CA ;
Benjamin, S ;
Cartwright, RA ;
Clough, JV ;
Gorst, DW ;
Kroll, ME ;
Ross, JRY ;
Wheatley, K ;
Whittaker, JA ;
Taylor, PRA ;
Proctor, SJ .
BRITISH JOURNAL OF CANCER, 1999, 79 (3-4) :658-665
[17]   Patterns of care and survival for children with acute lymphoblastic leukaemia diagnosed between 1980 and 1994 [J].
Stiller, CA ;
Eatock, EM .
ARCHIVES OF DISEASE IN CHILDHOOD, 1999, 81 (03) :202-208
[18]   FUNDAMENTAL DILEMMAS OF THE RANDOMIZED CLINICAL-TRIAL PROCESS - RESULTS OF A SURVEY OF THE 1,737 EASTERN-COOPERATIVE-ONCOLOGY-GROUP INVESTIGATORS [J].
TAYLOR, KM ;
FELDSTEIN, ML ;
SKEEL, RT ;
PANDYA, KJ ;
NG, P ;
CARBONE, PP .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (09) :1796-1805
[19]   Incremental costs of enrolling cancer patients in clinical trials: a population-based study [J].
Wagner, JL ;
Alberts, SR ;
Sloan, JA ;
Cha, S ;
Killian, J ;
O'Connell, MJ ;
Van Grevenhof, P ;
Lindman, J ;
Chute, CG .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (10) :847-853
[20]  
Weijer C, 1997, CAN MED ASSOC J, V156, P1153