Study of poly(L-lactide) microparticles based on supercritical CO2

被引：43

作者：

Chen, Ai-Zheng ^{[1
]}

Pu, Xi-Ming ^{[1
]}

Kang, Yun-Qing ^{[1
]}

Liao, Li ^{[1
]}

Yao, Ya-Dong ^{[1
]}

Yin, Guang-Fu ^{[1
]}

机构：

[1] Sichuan Univ, Coll Mat Sci& Engn, Chengdu 610064, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2007年 / 18卷 / 12期

关键词：

D O I：

10.1007/s10856-007-3173-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Poly(L-lactide) (PLLA) microparticles were prepared in supercritical anti-solvent process. The effects of several key factors on surface morphology, and particle size and particle size distribution were investigated. These factors included initial drops size, saturation ratio of PLLA solution, pressure, temperature, concentration of the organic solution, the flow rate of the solution and molecular weight of PLLA. The results indicated that the saturation ratio of PLLA solution, concentration of the organic solution and flow rate of the solution played important roles on the properties of products. Various microparticles with the mean particle size ranging from 0.64 to 6.64 mu m, could be prepared by adjusting the operational parameters. Fine microparticles were obtained in a process namely solution-enhanced dispersion by supercritical fluids (SEDS) process with dichloromethane/acetone mixture as solution.

引用

页码：2339 / 2345

页数：7

共 17 条

[1]

Co-precipitation of a herbicide and biodegradable materials by the supercritical anti-solvent technique [J].