The JAM family of proteins

被引：188

作者：

Mandell, KJ ^{[1
]}

Parkos, CA ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Epithelial Pathobiol Res Unit, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 06期

关键词：

junctional adhesion molecule; tight junctions; cell adhesion; homophilic interactions; leukocyte migration; barrier function;

D O I：

10.1016/j.addr.2005.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Junctional adhesion molecules (JAMs) are immunoglobulin superfamily (IgSF) proteins expressed at cell junctions in epithelial and endothelial cells as well as on the surface of leukocytes, platelets, and erythrocytes. Evidence suggests JAM proteins are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. This review will highlight what is currently known about the structure, function, and mechanism of action of JAM proteins as well as comment on potential directions for future JAM-related research. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：857 / 867

页数：11

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