Calixarene amino acids; building blocks for calixarene peptides and peptide-dendrimers

被引:51
作者
Xu, H [1 ]
Kinsel, GR [1 ]
Zhang, J [1 ]
Li, ML [1 ]
Rudkevich, DA [1 ]
机构
[1] Univ Texas, Dept Chem & Biochem, Arlington, TX 76019 USA
基金
美国国家科学基金会;
关键词
calixarenes; dendrimers; host compounds; supramolecular chemistry;
D O I
10.1016/S0040-4020(03)00947-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A modular strategy towards receptor macromolecules is presented, which combines synthetically diverse peptide synthesis with highly functional calixarene chemistry. The design and synthesis of calix[4]arene amino acids 1a-f, calix-lysines, is described, which were used as construction blocks to assemble nanoscale, multivalent entities-calix-peptides 2 and calix-peptide-dendrimers 3. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5837 / 5848
页数:12
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