TRP channels in mechanosensation

被引：104

作者：

Lin, SY

Corey, DP

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.conb.2005.05.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Channels of the TRIP superfamily have sensory roles in a wide variety of receptor cells, especially in mechanosensation. In some cases, the channels appear to be directly activated by mechanical force; in others, they appear to be downstream of a messenger pathway initiated by force on a non-channel sensor. A remaining challenge for most of these mechanosensory TRPs is to clarify the specific mechanism of activation.

引用

收藏

页码：350 / 357

页数：8

相关论文

共 41 条

[11] Probing the pore of the auditory hair cell mechanotransducer channel in turtle [J].

Farris, HE ;

LeBlanc, CL ;

Goswami, J ;

Ricci, AJ .

JOURNAL OF PHYSIOLOGY-LONDON, 2004, 558 (03) :769-792

[12] Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila [J].

Gong, ZF ;

Son, WS ;

Chung, YD ;

Kim, JW ;

Shin, DW ;

McClung, CA ;

Lee, Y ;

Lee, HW ;

Chang, DJ ;

Kaang, BK ;

Cho, HW ;

Oh, U ;

Hirsh, J ;

Kernan, MJ ;

Kim, CS .

JOURNAL OF NEUROSCIENCE, 2004, 24 (41) :9059-9066

[13] Co-assembly of polycystin-1 and-2 produces unique cation-permeable currents [J].

Hanaoka, K ;

Qian, F ;

Boletta, A ;

Bhumia, AK ;

Piontek, K ;

Tsiokas, L ;

Sukhatme, VP ;

Guggino, WB ;

Germino, GG .

NATURE, 2000, 408 (6815) :990-994

[14] Hypothesis: A helix of ankyrin repeats of the NOMPIC-TRP ion channel is the gating spring of mechanoreceptors [J].

Howard, J ;

Bechstedt, S .

CURRENT BIOLOGY, 2004, 14 (06) :R224-R226

[15] COMPLIANCE OF THE HAIR BUNDLE ASSOCIATED WITH GATING OF MECHANOELECTRICAL TRANSDUCTION CHANNELS IN THE BULLFROGS SACCULAR HAIR CELL [J].

HOWARD, J ;

HUDSPETH, AJ .

NEURON, 1988, 1 (03) :189-199

[16] Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivo [J].

Kahn-Kirby, AH ;

Dantzker, JLM ;

Apicella, AJ ;

Schafer, WR ;

Browse, J ;

Bargmann, CI ;

Watts, JL .

CELL, 2004, 119 (06) :889-900

[17] Towards understanding the polycystins [J].

Kaletta, T ;

Van der Craen, M ;

Van Geel, A ;

Dewulf, N ;

Bogaert, T ;

Branden, M ;

King, KV ;

Buechner, M ;

Barstead, R ;

Hyink, D ;

Li, HP ;

Geng, L ;

Burrow, C ;

Wilson, P .

NEPHRON EXPERIMENTAL NEPHROLOGY, 2003, 93 (01) :E9-E17

[18] A TRPV family ion channel required for hearing in Drosophila [J].

Kim, J ;

Chung, YD ;

Park, DY ;

Choi, SK ;

Shin, DW ;

Soh, H ;

Lee, HW ;

Son, W ;

Yim, J ;

Park, CS ;

Kernan, MJ ;

Kim, C .

NATURE, 2003, 424 (6944) :81-84

[19] Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor [J].

Liedtke, W ;

Choe, Y ;

Martí-Renom, MA ;

Bell, AM ;

Denis, CS ;

Sali, A ;

Hudspeth, AJ ;

Friedman, JM ;

Heller, S .

CELL, 2000, 103 (03) :525-535

[20] Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans [J].

Liedtke, W ;

Tobin, DM ;

Bargmann, CI ;

Friedman, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 :14531-14536

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