Total synthesis of (+)-epopromycin B and its analogues - studies on the inhibition of cellulose biosynthesis

被引:10
作者
Dobler, MR [1 ]
机构
[1] Novartis Crop Protect AG, Lead Discovery, CH-4002 Basel, Switzerland
关键词
D O I
10.1016/S0040-4039(00)01944-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The described inhibition of the cellulose biosynthesis by epopromycin B prompted us to establish a short and efficient synthesis of the natural product, suitable for accessing a broad range of unnatural analogues in a multiparallel fashion. During the course of our synthesis the absolute configuration of (+)-epopromycin B could be determined. (C) 2000 Elsevier Science Ltd. All rights reserved.
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收藏
页码:215 / 218
页数:4
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