Inactivation of Myc-induced p53-dependent apoptosis in human tumors

被引：27

作者：

Henriksson, M

Selivanova, G

Lindström, M

Wiman, KG ^{[1
]}

机构：

[1] Karolinska Inst, Microbiol & Tumor Biol Ctr, Stockholm, Sweden

[2] Karolinska Inst, Dept Oncol Pathol, CCK, Stockholm, Sweden

来源：

APOPTOSIS | 2001年 / 6卷 / 1-2期

关键词：

apoptosis; ARF; cancer therapy; Myc; p53;

D O I：

10.1023/A:1009644716727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Myc family of oncoproteins promote cell growth and are frequently overexpressed in human tumors. However, Myc can also trigger cell death by apoptosis. This is at least in part mediated via the ARF-p53 pathway. Myc activation leads to a selection for inactivation of ARF or p53, allowing cell survival and tumor progression. Restoration of p53-dependent apoptosis by various means is an attractive approach for new cancer therapy.

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收藏

页码：133 / 137

页数：5

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