Lack of pharmacokinetic drug interaction between tenofovir disoproxil fumarate and nelfinavir mesylate

被引：16

作者：

Boffito, M

Pozniak, A

Kearney, BP

Higgs, C

Mathias, A

Zhong, LJ

Shah, J

机构：

[1] Chelsea & Westminster Hosp, PK Res, St Stephens Ctr, London SW10 9NH, England

[2] Gilead Sci Inc, Foster City, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 10期

关键词：

D O I：

10.1128/AAC.49.10.4386-4389.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A study explored the pharmacokinetics of tenofovir (300 mg administered once daily) and nelfinavir (1,250 mg twice daily) when coadministered in 29 healthy volunteers. Tenofovir, nelfinavir, and M8 pharmacolkinetics was unaltered when tenofovir and neltinavir were coadministered, and tenofovir administration did not affect the M8/nelfinavir area under the concentration-versus-time curve over the dosing interval (AUC(tau)) ratio. No interaction between tenofovir and nelfinavir was observed.

引用

页码：4386 / 4389

页数：4